Natural Product Chemistry

NMR based structural elucidation of known and novel biologically active compounds

Director: Fatma Kaplan, Ph.D.

Dr. Kaplan leads the NMR based structural elucidation of novel and known compounds. The projects are selected based on their potentially important contribution to agriculture, food security, humanity and science. Below are the completed projects in 2010 and after.

Contact: schiller at kaplanschiller.com, brief description of the project

Completed projects:

  1. Proc. Nat. Acad. Sci. (2015) 112: 11407–11412, doi: 10.1073/pnas.1511131112. NMR based structural elucidation of death acids. MagLab Science Highlights
  2. PLoS ONE (2015) 10(9): e0137836. NMR based structural verification of a toxic compound, parthenin.
  3. J. Agric. Food. Chem. (2015) 63: 335–342. NMR experiments and verification of  ipomeamarone and dehydro-ipomeamarone using NMR. MagLab Science Highlights
  4. J. Nat. Prod. (2014) 77:402-405. NMR experiments and verification of presence of methyl farnesoate collected from insect blood with synthetic methyl farnesoate. MagLab Science Highlights
  5. PLoS ONE (2012) 7: e38146. NMR based structural verification of pregijerene.
  6. J. Chem. Ecol. (2012) 38: 408–417. NMR based structural elucidation of the citrus Diaprepes root weevil mating pheromone that had eluded structure determination efforts for over 10 years. US Patent No: US 8,663,621
  7. Proc. Nat. Acad. Sci. (2011) 108: 5455–5460. NMR based structural elucidation of novel and known kauralexins.
  8. Plant Physiol. (2011) 156: 2082–2097. NMR based structural elucidation of novel and known zealexins.
  9. Nature (2008) 454: 1115-1118. This was Dr. Kaplan’s postdoctoral training in natural product chemistry. She led the project for mating pheromone purification from C. elegans.  Dr. Kaplan purified the mating pheromone blend using activity guided purification and elucidated the structure using NMR.   US Patent No: US 8,318,146 B1